diff --git a/trunk/auto/depends.sh b/trunk/auto/depends.sh
index 8b0480f0b..24fced3bf 100755
--- a/trunk/auto/depends.sh
+++ b/trunk/auto/depends.sh
@@ -551,6 +551,8 @@ if [[ $SRS_SSL == YES && $SRS_USE_SYS_SSL != YES ]]; then
             echo "Warning: Local openssl is on, ignore system openssl"
         fi
     fi
+    # Patch for loongarch mips64
+    g++ -dM -E - </dev/null |grep '#define __mips64 1' -q && OPENSSL_CONFIG="./Configure linux64-mips64"
     # For RTC, we should use ASM to improve performance, not a little improving.
     if [[ $SRS_RTC == NO || $SRS_NASM == NO ]]; then
         OPENSSL_OPTIONS="$OPENSSL_OPTIONS -no-asm"